Lissone — Lissone, 193 км |
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| 1 | Sjoerd Bax | (Ned) | Alpecin-Deceuninck | 4:53:26 |
| 2 | Alejandro Valverde | (Esp) | Movistar | |
| 3 | Andrea Piccolo | (Ita) | EF-EasyPost | |
| 4 | Davide Formolo | (Ita) | UAE Emirates | |
| 5 | Domenico Pozzovivo | (Ita) | Intermarché | |
| 6 | Guillaume Martin | (Fra) | Cofidis | |
| 7 | Rigoberto Urán | (Col) | EF-EasyPost | |
| 8 | Vincenzo Nibali | (Ita) | Astana | |
| 9 | Enric Mas | (Esp) | Movistar | 0:07 |
| 10 | Stefano Oldani | (Ita) | Alpecin-Deceuninck | 1:40 |
| 11 | Kobe Goossens | (Bel) | Intermarché | |
| 12 | Simon Yates | (Gbr) | BikeExchange | 1:43 |
| 13 | Corbin Strong | (Nzl) | Israel-Premier Tech | 1:56 |
| 14 | Umberto Marengo | (Ita) | Drone Hopper | |
| 15 | Andreas Kron | (Den) | Lotto-Soudal | |
| 16 | José Joaquín Rojas | (Esp) | Movistar | |
| 17 | Simone Velasco | (Ita) | Astana | |
| 18 | Davide Bais | (Ita) | Eolo-Kometa | |
| 19 | Davide Villella | (Ita) | Cofidis | |
| 20 | Matteo Jorgenson | (Usa) | Movistar | |
| 21 | Alexis Vuillermoz | (Fra) | TotalEnergies | |
| 22 | Kristian Sbaragli | (Ita) | Alpecin-Deceuninck | |
| 23 | Pierre-Roger Latour | (Fra) | TotalEnergies | |
| 24 | Alessandro Covi | (Ita) | UAE Emirates | |
| 25 | Marco Tizza | (Ita) | Bingoal | |
| 26 | Laurens Huys | (Bel) | Intermarché | |
| 27 | Odd Christian Eiking | (Nor) | EF-EasyPost | |
| 28 | Sean Quinn | (Usa) | EF-EasyPost | |
| 29 | Ion Izagirre | (Esp) | Cofidis | |
| 30 | Filippo Fiorelli | (Ita) | Bardiani-CSF | |
| 31 | Filippo Conca | (Ita) | Lotto-Soudal | |
| 32 | Stefan de Bod | (Rsa) | Astana | |
| 33 | Jason Osborne | (Ger) | Alpecin-Deceuninck | |
| 34 | Simone Petilli | (Ita) | Intermarché | |
| 35 | Benjamin Thomas | (Fra) | Cofidis | |
| 36 | Einer Augusto Rubio | (Col) | Movistar | |
| 37 | Lorenzo Fortunato | (Ita) | Eolo-Kometa | |
| 38 | Diego Ulissi | (Ita) | UAE Emirates | |
| 39 | Santiago Umba | (Col) | Drone Hopper | |
| 40 | Carl Fredrik Hagen | (Nor) | Israel-Premier Tech | |
| 41 | Marc Hirschi | (Sui) | UAE Emirates | |
| 42 | Mark Padun | (Ukr) | EF-EasyPost | |
| 43 | Rubén Fernández | (Esp) | Cofidis | |
| 44 | Carlos Barbero | (Esp) | Lotto-Soudal | |
| 45 | Alessandro De Marchi | (Ita) | Israel-Premier Tech | 2:02 |
| 46 | Dylan Teuns | (Bel) | Israel-Premier Tech | 2:07 |
| 47 | Christian Scaroni | (Ita) | Astana | 2:11 |
| 48 | Remy Rochas | (Fra) | Cofidis | 2:45 |
| 49 | Jon Agirre | (Esp) | Kern Pharma | |
| 50 | Andrea Pasqualon | (Ita) | Intermarché | 8:18 |
| 51 | Samuele Zoccarato | (Ita) | Bardiani-CSF | |
| 52 | Giovanni Carboni | (Ita) | Kern Pharma | |
| 53 | Andrea Garosio | (Ita) | Biesse-Carrera | |
| 54 | Mathieu Burgaudeau | (Fra) | TotalEnergies | |
| 55 | Rémy Mertz | (Bel) | Bingoal | |
| 56 | Marco Murgano | (Ita) | Corratec | |
| 57 | Anders Foldager | (Den) | Biesse-Carrera | |
| 58 | Diego Pablo Sevilla | (Esp) | Eolo-Kometa | |
| 59 | Víctor de la Parte | (Esp) | TotalEnergies | |
| 60 | Calum Johnston | (Gbr) | Caja Rural-RGA | |
| 61 | Héctor Carretero | (Esp) | Kern Pharma | |
| 62 | Edward Ravasi | (Ita) | Eolo-Kometa | |
| 63 | Jefferson Cepeda | (Ecu) | Caja Rural-RGA | |
| 64 | Francesco Gavazzi | (Ita) | Eolo-Kometa | |
| 65 | Alberto Bettiol | (Ita) | EF-EasyPost | |
| 66 | Lawson Craddock | (Usa) | BikeExchange | |
| DNS | Michael Woods | (Can) | Israel-Premier Tech | |
| DNS | Robert Stannard | (Aus) | Alpecin-Deceuninck | |
| DNF | Carlos García | (Esp) | Kern Pharma | |
| DNF | Andoni López de Abetxuko | (Esp) | Caja Rural-RGA | |
| DNF | Joel Nicolau | (Esp) | Caja Rural-RGA | |
| DNF | José Félix Parra | (Esp) | Kern Pharma | |
| DNF | Josu Etxeberria | (Esp) | Caja Rural-RGA | |
| DNF | Jorge Arcas | (Esp) | Movistar | |
| DNF | Jon Barrenetxea | (Esp) | Caja Rural-RGA | |
| DNF | Jordi López | (Esp) | Kern Pharma | |
| DNF | Jesús Herrada | (Esp) | Cofidis | |
| DNF | Igor Arrieta | (Esp) | Kern Pharma | |
| DNF | Mattias Nordal | (Den) | Biesse-Carrera | |
| DNF | Vegard Stake Laengen | (Nor) | UAE Emirates | |
| DNF | Arjen Livyns | (Bel) | Bingoal | |
| DNF | Matteo Amella | (Ita) | Corratec | |
| DNF | Luca Rastelli | (Ita) | Bardiani-CSF | |
| DNF | Alessio Bonelli | (Ita) | Biesse-Carrera | |
| DNF | Edoardo Martinelli | (Ita) | Mg.K Vis-Color for Peace | |
| DNF | Maxim Van Gils | (Bel) | Lotto-Soudal | |
| DNF | Arthur Kluckers | (Lux) | UAE Emirates | |
| DNF | Andrea Montoli | (Ita) | Eolo-Kometa | |
| DNF | Paul Ourselin | (Fra) | TotalEnergies | |
| DNF | Alessandro Iacchi | (Ita) | Qhubeka | |
| DNF | Gianni Moscon | (Ita) | Astana | |
| DNF | Omar El Gouzi | (Ita) | Bardiani-CSF | |
| DNF | Jan Stöckli | (Sui) | Corratec | |
| DNF | Ben Granger | (Gbr) | Mg.K Vis-Color for Peace | |
| DNF | Antonio Puppio | (Ita) | Israel-Premier Tech | |
| DNF | Dion Smith | (Nzl) | BikeExchange | |
| DNF | Edoardo Zardini | (Ita) | Drone Hopper | |
| DNF | Ephrem Ghebrehiwet | (Eri) | Qhubeka | |
| DNF | Enrico Battaglin | (Ita) | Bardiani-CSF | |
| DNF | Dimitri Peyskens | (Bel) | Bingoal | |
| DNF | Simone Olivero | (Ita) | Corratec | |
| DNF | Paul Double | (Gbr) | Mg.K Vis-Color for Peace | |
| DNF | Rein Taaramae | (Est) | Intermarché | |
| DNF | Damien Howson | (Aus) | BikeExchange | |
| DNF | Jhonatan Restrepo | (Col) | Drone Hopper | |
| DNF | Giacomo Villa | (Ita) | Biesse-Carrera | |
| DNF | Alex Bogna | (Aus) | Alpecin-Deceuninck | |
| DNF | Johan Meens | (Bel) | Bingoal | |
| DNF | Davide Baldaccini | (Ita) | Corratec | |
| DNF | Travis Stedman | (Rsa) | Qhubeka | |
| DNF | Hideto Nakane | (Jpn) | EF-EasyPost | |
| DNF | Mattia Bais | (Ita) | Drone Hopper | |
| DNF | Lorenzo Galimberti | (Ita) | Biesse-Carrera | |
| DNF | Matthew Kingston | (Gbr) | Mg.K Vis-Color for Peace | |
| DNF | Kevin Colleoni | (Ita) | BikeExchange | |
| DNF | George Bennett | (Nzl) | UAE Emirates | |
| DNF | Julien Desmarets | (Bel) | Bingoal | |
| DNF | Alan Jousseaume | (Fra) | TotalEnergies | |
| DNF | Jacopo Menegotto | (Ita) | Qhubeka | |
| DNF | Andrey Zeits | (Kaz) | Astana | |
| DNF | Davide Gabburo | (Ita) | Bardiani-CSF | |
| DNF | Jhojan García | (Col) | Caja Rural-RGA | |
| DNF | Michael Belleri | (Ita) | Biesse-Carrera | |
| DNF | Daan Hoeks | (Ned) | Mg.K Vis-Color for Peace | |
| DNF | Kamil Malecki | (Pol) | Lotto-Soudal | |
| DNF | Andrea Pietrobon | (Ita) | Eolo-Kometa | |
| DNF | Jeremy Cabot | (Fra) | TotalEnergies | |
| DNF | Ghebrehiwet Birhane | (Eri) | Qhubeka | |
| DNF | Fabio Felline | (Ita) | Astana | |
| DNF | Luca Covili | (Ita) | Bardiani-CSF | |
| DNF | Manuel Zobrist | (Sui) | Corratec | |
| DNF | Maximilian Stedman | (Gbr) | Mg.K Vis-Color for Peace | |
| DNF | Jakob Fuglsang | (Den) | Israel-Premier Tech | |
| DNF | Tanel Kangert | (Est) | BikeExchange | |
| DNF | Simone Ravanelli | (Ita) | Drone Hopper | |
| DNF | Mattia Guasco | (Ita) | Qhubeka | |
| DNF | Jimmy Janssens | (Bel) | Alpecin-Deceuninck | |
| DNF | Tom Paquot | (Bel) | Bingoal | |
| DNF | Francesco Carollo | (Ita) | Mg.K Vis-Color for Peace | |
| DNF | Théo Delacroix | (Fra) | Intermarché | |
| DNF | Tsgabu Grmay | (Eti) | BikeExchange | |
| DNF | Alessandro Bisolti | (Ita) | Drone Hopper | |
| DNF | Raffaele Mosca | (Ita) | Qhubeka | |
| DNF | Nicola Schleuniger | (Sui) | Corratec | |
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